Choroid plexus enlargement correlates with demyelinating lesions and thalamic atrophy in radiologically isolated syndrome
ChP enlargement is evident at the earliest stage of MS, is associated with demyelination and neurodegeneration, highlighting ChP volume as a potential diagnostic biomarker. Although baseline ChPvol alone did not predict progression to CDMS, its similarity in RIS and MS cohorts supports the forthcoming 2024 revised McDonald criteria suggesting that RIS can be considered MS in specific situations.
Authors
- Zixuan Hu (ORCID: https://orcid.org/0009-0000-7968-8757)
- Aditya Bharatha (ORCID: https://orcid.org/0000-0002-7923-7865)
- Uten Yarach (ORCID: https://orcid.org/0000-0002-5923-2864)
- Timothy Lim (ORCID: https://orcid.org/0000-0002-4900-4892)
- Melanie Guenette (ORCID: https://orcid.org/0000-0001-7112-704X)
- Errol Colak (ORCID: https://orcid.org/0000-0002-3771-7975)
- Lisa Eunyoung Lee (ORCID: https://orcid.org/0000-0002-8334-3740)
- Suradech Suthiphosuwan (ORCID: https://orcid.org/0000-0002-8171-0164)
- Jiwon Oh
- Nontharat Tucksinapinunchai (ORCID: https://orcid.org/0009-0008-9603-7372)
Institutions
- St. Michael's Hospital (CA)
- Johns Hopkins University (US)
- University of Toronto (CA)
- Chiang Mai University (TH)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1177/13524585251375365
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00