Perinatal Outcomes in HIV-Positive Pregnant Women: A Multicentric Study

Purpose: To evaluate perinatal outcomes and maternal human immunodeficiency virus (HIV) disease progression in pregnant women Methods: Retrospective multicentric review of a cohort of 34 HIV-positive pregnant women delivering at four Turkish hospitals (2009-2021).Data included obstetric/neonatal parameters and serial laboratory values.Results: Mean maternal age was 30.83.3 years and 52.9% were diagnosed during pregnancy.HIV viral load remained suppressed [median 254 copies/mL interquartile range (IQR: 50-1200) in first trimester and 211 copies/mL (IQR: 40-900) at delivery].Mean birth weight was 2351.8727.0g.Pregnancy complications included premature rupture of membranes (29.4%), preterm labor (23.5%), and placental abruption (5.9%).Among 32 infants followed-up, none acquired HIV (0% mother-to-child transmission but two lost to follow-up).No maternal disease progression occurred. Conclusion:Antiretroviral therapy and cesarean delivery resulted in 0% mother-to-child HIV transmission in tested infants in this cohort.High obstetric complication rates and frequent late diagnosis underscored the need for enhanced prenatal screening and individualized delivery planning.Neonatal outcome data were limited to parameters with complete and consistent documentation.