Autoimmune Haemolytic Anaemia: A report of two cases with varied clinical course managed at the Kenyatta National Hospital, Nairobi, Kenya

Autoimmune Haemolytic Anaemia (AIHA) is a rare yet serious condition characterized by immune-mediated red cell destruction. It presents with anaemia, jaundice, and splenomegaly, requiring a high index of suspicion for timely diagnosis. We present two cases managed at the Kenyatta National Hospital (KNH), highlighting varied disease courses and treatment responses. Management includes corticosteroids as first-line therapy, with immunosuppressants or biologics like rituximab for refractory cases. Limited access to diagnostic tests and treatment options remains a challenge in Kenya. Addressing these barriers through improved clinician awareness and healthcare infrastructure is crucial for optimizing AIHA outcomes in resource-limited settings.

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Publication Details

Journal
Journal of Kenya Assocation of Physicians
Published
2025-09-16
DOI
https://doi.org/10.4314/jkap.v7i2.5
Primary Topic
Blood groups and transfusion
Type
article
Field-Weighted Citation Impact
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article

Autoimmune Haemolytic Anaemia: A report of two cases with varied clinical course managed at the Kenyatta National Hospital, Nairobi, Kenya

Matilda Ong’ondi, Debbie Mwende Mutua
Journal of Kenya Assocation of Physicians
Blood groups and transfusion
article

Autoimmune Haemolytic Anaemia: A report of two cases with varied clinical course managed at the Kenyatta National Hospital, Nairobi, Kenya

Matilda Ong’ondi, Debbie Mwende Mutua
article en

Abstract

Autoimmune Haemolytic Anaemia (AIHA) is a rare yet serious condition characterized by immune-mediated red cell destruction. It presents with anaemia, jaundice, and splenomegaly, requiring a high index of suspicion for timely diagnosis. We present two cases managed at the Kenyatta National Hospital (KNH), highlighting varied disease courses and treatment responses. Management includes corticosteroids as first-line therapy, with immunosuppressants or biologics like rituximab for refractory cases. Limited access to diagnostic tests and treatment options remains a challenge in Kenya. Addressing these barriers through improved clinician awareness and healthcare infrastructure is crucial for optimizing AIHA outcomes in resource-limited settings.

Journal of Kenya Assocation of PhysiciansVol. 7(2)
Openalex Percentile: Top 66%
Blood groups and transfusion
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