Mapping the Gaps: A Meta-Review of Systematic Reviews on Global Depression Prevalence and its Policy Implications

Introduction and Background: Depression is a leading cause of disability globally, yet understanding its prevalence remains fragmented. Despite increasing systematic reviews, synthesis across populations and regions is still limited. Background: Systematic Reviews and Meta-Analyses (SRMAs) on depression prevalence have proliferated in the last decade. However, methodological inconsistencies, limited geographic coverage, and a lack of policy focus restrict their utility for global strategy. Purpose and Objectives: This first comprehensive meta-review of existing literature aims to identify gaps and to evaluate global/ continental reach; assess methodological quality and policy alignment; highlight under represented regions and populations to inform future research and policy. Methodology: Following PRISMA 2020, we systematically searched four databases (2014-2024). Included re- views met quality, scope, and reporting criteria; excluded single country, clinical only, non-English publications. A total of 36 SR-MAs was included. Results: The findings show a strong continental skew: 55% of studies focus on Asia. Africa and Australia are grossly underrepresented. Most reviews focus on clinical populations, adolescents, or the elderly, neglecting vulnerable groups like informal workers, displaced people, and those facing economic shocks. Recommendations and Conclusion: We recommend that future research should: Prioritize geographic inclusivity for underrepresented regions. Include broader populations, especially socially vulnerable groups. Align closely with public health goals. While the current evidence base offers insights, there is a need to bridge the gaps. Bridging these gaps is essential for equitable, data-driven policies meeting the depression needs of all communities, especially those often excluded.