Activation of T Cell–Intrinsic p53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherapy
This study identifies T cell-intrinsic p53 as a key determinant of immunotherapy efficacy. CTD acetylation, rather than stabilization, activates a p53-IFN-γ feedback loop and promotes CD8+ T cell-mediated antitumor immunity independently of tumor p53 status. These findings reveal a non-tumor cell-autonomous action of p53 to boost PD-1-based immunotherapy.
Authors
- Wei Gu (ORCID: https://orcid.org/0000-0002-1480-2368)
- Shidong Zhao (ORCID: https://orcid.org/0000-0002-7823-8217)
- Yajing Liu (ORCID: https://orcid.org/0000-0001-5757-2518)
- Zhanlong Shen (ORCID: https://orcid.org/0000-0002-6897-5125)
- Han Yao (ORCID: https://orcid.org/0000-0002-3409-8136)
- Wenbin Xu (ORCID: https://orcid.org/0000-0003-4862-0498)
- Zhen Wu (ORCID: https://orcid.org/0000-0002-6730-1225)
- Donglai Wang (ORCID: https://orcid.org/0000-0002-2247-1765)
- Xiaojun Yan (ORCID: https://orcid.org/0000-0002-0827-7499)
- Dongkui Xu (ORCID: https://orcid.org/0000-0003-0605-8273)
- Jingyuan Ning
- Meng Zhang (ORCID: https://orcid.org/0009-0004-5279-5164)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- National Cancer Center (US)
- Peking University Cancer Hospital (CN)
- Peking University People's Hospital (CN)
- Cancer Genetics (United States) (US)
- Columbia University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0649
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00