Severe Iron Deficiency Anemia in Children with Dystrophic Epidermolysis Bullosa: Three Cases

Background. Iron deficiency anemia is one of the most common complications of dystrophic epidermolysis bullosa (DEB). Anemia management in such cases is complicated due to many pathological factors and conditions aggravating disease course and iron absorption leading to development of anemia vicious pathological circle. Case description. Cases of anemia in children with DEB have been described. Diagnostic algorithms and therapeutic criteria have been presented. Iron (III) hydroxide sucrose was administrated, transfusion of leukoreduced red blood cell suspension was performed. Increase in hemoglobin concentration, hemodynamics stabilization, and wound healing were noted on therapy. No side effects were reported during treatment. Conclusion. Children with DEB and comorbid severe anemia require complex therapy including iron medications and transfusions. Moreover, it is crucial to update management protocols for such patients.