Response to: Survival after risk-reducing mastectomy in young BRCA1 carriers with breast cancer
We address methodological considerations in evaluating risk-reducing mastectomy among young BRCA carriers with prior history of breast cancer, emphasizing time-dependent analysis, realistic assumptions on mortality and contralateral breast cancer risk, and appropriate confounder adjustment as ways to improve accuracy in survival outcome estimates.
Authors
- Eva Blondeaux (ORCID: https://orcid.org/0000-0001-9566-4579)
- Matteo Lambertini (ORCID: https://orcid.org/0000-0003-1797-5296)
- Virginia Delucchi
Institutions
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- BJC Reports
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1038/s44276-025-00179-6
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00