Iron‐Catalyzed Stereoselective C–H Acylation of 2‐Acetamido Acrylates
An iron‐catalyzed oxidative acylation of acylamido acrylates with abundant aldehydes has been developed. The use of mono N‐protected amino acids results in the unusual assembly of α,β ‐unsaturated compounds in a predictable (Z)‐stereoselective fashion, thereby offering a complementary tool toward the synthesis of unnatural γ ‐carbonyl α‐amino acid derivatives. Density functional theory studies provide insights into the stereodetermining step of the radical reaction pathway.
Authors
- Thanh V. Q. Nguyen (ORCID: https://orcid.org/0000-0003-4320-0523)
- Werngard Czechtizky (ORCID: https://orcid.org/0000-0003-4487-2399)
- Enrique Gómez‐Bengoa (ORCID: https://orcid.org/0000-0002-8753-3760)
- C. Kyriacou (ORCID: https://orcid.org/0009-0001-2693-0623)
- Arkaitz Correa (ORCID: https://orcid.org/0000-0002-9004-3842)
Institutions
- University of the Basque Country (ES)
- AstraZeneca (Netherlands) (NL)
- AstraZeneca (Sweden) (SE)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1002/adsc.70047
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Eusko Jaurlaritza
- Euskal Herriko Unibertsitatea
- European Regional Development Fund
- European Social Fund