Joint association of body mass index and lipoprotein(a) with atrial fibrillation prevalence: an observational and mendelian randomization study
Lower BMI and Lp(a) levels were associated with a reduced prevalence of AF as well as a lower risk of stroke, HF, and MACE. Mediation analysis showed that neither BMI nor Lp(a) mediated the effect of the other, suggesting that their contributions to AF risk operate through independent pathways.
Authors
- Jiawei Lu (ORCID: https://orcid.org/0000-0003-1199-8526)
- Qi Jiang (ORCID: https://orcid.org/0000-0001-7835-1335)
- Jian-Qiang Hu (ORCID: https://orcid.org/0000-0003-2989-8048)
- Kang Zhang
- Ling Yang (ORCID: https://orcid.org/0000-0002-5506-7021)
- Huan Shi (ORCID: https://orcid.org/0009-0004-2419-9816)
- Wenxing Guo (ORCID: https://orcid.org/0000-0002-5669-4836)
- Xinpeng You
Institutions
- Soochow University (CN)
- Changzhou Third People's Hospital (CN)
Publication Details
- Journal
- Polskie Archiwum Medycyny Wewnętrznej
- Published
- 2025-09-19
- DOI
- https://doi.org/10.20452/pamw.17123
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bristol
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Medical Research Council