Limited pre-clinical relevance of the heterozygous RYR1-I4895T/+ mouse model due to its mild phenotype

Our results prompt the need for caution when using this model, and point to its potential limited relevance for preclinical studies.

Authors

Ludivine Rotard (ORCID: https://orcid.org/0009-0008-0150-1604)
Laurent Pelletier (ORCID: https://orcid.org/0000-0002-1015-9547)
Julien Fauré (ORCID: https://orcid.org/0000-0002-3660-9809)
Isabelle Marty (ORCID: https://orcid.org/0000-0003-3625-913X)
Julie Brocard (ORCID: https://orcid.org/0000-0001-9345-5191)
Benoı̂t Giannesini
John Rendu (ORCID: https://orcid.org/0000-0002-0377-0807)
Vincent Jacquemond (ORCID: https://orcid.org/0000-0003-4944-270X)
François Jouve (ORCID: https://orcid.org/0000-0003-2065-0863)
Caroline Benstaali
Margaux Melka

Institutions

Université Claude Bernard Lyon 1 (FR)
Centre National de la Recherche Scientifique (FR)
Inserm (FR)
Centre Hospitalier Universitaire de Grenoble (FR)
Institut NeuroMyoGène (FR)
Centre de Résonance Magnétique Biologique et Médicale (FR)
Grenoble Institute of Neurosciences (FR)
Université Grenoble Alpes (FR)

Publication Details

Journal: Journal of Neuromuscular Diseases
Published: 2025-09-19
DOI: https://doi.org/10.1177/22143602251339354
Citations: 1
Primary Topic: Ion channel regulation and function
Type: article
Field-Weighted Citation Impact: 0.81

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article

Limited pre-clinical relevance of the heterozygous RYR1-I4895T/+ mouse model due to its mild phenotype

Ludivine Rotard, Laurent Pelletier, Julien Fauré, Isabelle Marty et al.

Sep 19, 2025

1 citations

Journal of Neuromuscular Diseases

Ion channel regulation and function

0.81

article

Limited pre-clinical relevance of the heterozygous RYR1-I4895T/+ mouse model due to its mild phenotype

Ludivine Rotard, Laurent Pelletier, Julien Fauré, Isabelle Marty, Julie Brocard, Benoı̂t Giannesini, John Rendu, Vincent Jacquemond, François Jouve, Caroline Benstaali, Margaux Melka

September 19, 2025article en

1 citations

Abstract

Our results prompt the need for caution when using this model, and point to its potential limited relevance for preclinical studies.

Journal of Neuromuscular Diseases

Université Claude Bernard Lyon 1 (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Centre Hospitalier Universitaire de Grenoble (FR), Institut NeuroMyoGène (FR), Centre de Résonance Magnétique Biologique et Médicale (FR), Grenoble Institute of Neurosciences (FR), Université Grenoble Alpes (FR)

Openalex Percentile: Top 23%

Ion channel regulation and function

0.81

DOI Source OpenAlex

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Limited pre-clinical relevance of the heterozygous RYR1-I4895T/+ mouse model due to its mild phenotype — Ludivine Rotard, Laurent Pelletier, et al. · Journal of Neuromuscular Diseases (2025) | TGRS Research Map | TGRS