Abstract IA024: Frontiers of tumor evolution in ovarian cancer

Abstract In this talk I will discuss new insights into the nature of tumor evolution in high grade serous ovarian cancer (HGSOC). I will focus on two key areas that have been informed by recent advances in single cell whole genome sequencing. First, I will discuss the nature of how HGSOCs acquire genome doubled states in their evolutionary histories. I will show that genome doubling is an ongoing process throughout evolution with important consequences for phenotypic states and immunosuppression. Second, I will discuss recent work to track evolution from diagnosis to relapse using structural variants and cell-free DNA technology. I will show how clonal populations either contract or persist over a multi-year intervals in patients with relapsed disease and highlight genomic structural features linked to the evolution of drug resistance. Citation Format: Sohrab Shah. Frontiers of tumor evolution in ovarian cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Ovarian Cancer Research; 2025 Sep 19-21; Denver, CO. Philadelphia (PA): AACR; Cancer Res 2025;85(18_Suppl):Abstract nr IA024.