Abstract PR017: Survival divide: A comparative analysis of black women and white women with ovarian cancer in the United States

Abstract Black women experience disproportionately poor outcomes in ovarian cancer, yet the survival trends contributing to these inequities remain underexplored. This study aimed to evaluate five-year survival differences between Black and White women diagnosed with ovarian cancer using national registry data. A retrospective analysis was conducted using the Surveillance, Epidemiology, and End Results (SEER) dataset, including 773 Black and 6,304 White women diagnosed with ovarian cancer between 2012 and 2021. Kaplan-Meier survival curves were utilized to compare 1, 3, and 5-year survival rates across racial groups. Results revealed an evident survival gap. Black women began with a 1-year survival rate of 61.2%, which declined drastically to 10.8% by year 5. In contrast, White women had a higher 1-year survival rate of 77.9%, declining more gradually to 22.4% by year 5. The survival curve demonstrated a statistically significant difference in survival probability between groups. These findings suggest that systemic partialities, delayed diagnosis, and reduced access to high-quality treatment may contribute to the accelerated mortality observed among Black women. This research emphasizes the urgent need for targeted interventions, including earlier detection and tailored treatment pathways, to close the survival gap in ovarian cancer outcomes. Citation Format: Alexandria E. Fletcher. Survival divide: A comparative analysis of black women and white women with ovarian cancer in the United States [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Ovarian Cancer Research; 2025 Sep 19-21; Denver, CO. Philadelphia (PA): AACR; Cancer Res 2025;85(18_Suppl):Abstract nr PR017.