Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice
Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.
Authors
- Steve Horvath (ORCID: https://orcid.org/0000-0002-4110-3589)
- Scott F. Leiser (ORCID: https://orcid.org/0000-0002-8003-2955)
- Nisi Jiang (ORCID: https://orcid.org/0000-0003-1837-7618)
- Alexander Tyshkovskiy (ORCID: https://orcid.org/0000-0002-6215-190X)
- Vadim N. Gladyshev (ORCID: https://orcid.org/0000-0002-0372-7016)
- Malcolm Whitman (ORCID: https://orcid.org/0000-0002-3198-3439)
- James F. Nelson (ORCID: https://orcid.org/0000-0002-7439-3033)
- Tracy Keller (ORCID: https://orcid.org/0000-0003-0530-0566)
- Vivian Diaz (ORCID: https://orcid.org/0000-0002-9492-6554)
- Melissa Han (ORCID: https://orcid.org/0000-0002-5923-0594)
- Molly A. Bogue (ORCID: https://orcid.org/0000-0001-6624-9261)
- Randy Strong (ORCID: https://orcid.org/0000-0001-6643-3288)
- Christiaan Leeuwenburgh (ORCID: https://orcid.org/0000-0003-0826-4257)
- Ken Raj (ORCID: https://orcid.org/0000-0002-3744-265X)
- Marisa Lopez‐Cruzan (ORCID: https://orcid.org/0000-0003-0285-1012)
- Peter Walter
- Brett C. Ginsburg
- Nadia Rosenthal (ORCID: https://orcid.org/0000-0002-7599-7365)
- Rolf F. Kletzien
- Adam B. Salmon (ORCID: https://orcid.org/0000-0002-1475-7843)
- Ron Korstanje (ORCID: https://orcid.org/0000-0002-2808-1610)
- Susanna Rosi (ORCID: https://orcid.org/0000-0002-9269-3638)
- Peter C. Reifsnyder (ORCID: https://orcid.org/0000-0001-5666-8040)
- Jerry R. Colca (ORCID: https://orcid.org/0000-0003-3933-8626)
- Richard A. Miller (ORCID: https://orcid.org/0000-0001-9266-9649)
- Catherine C. Kaczorowski (ORCID: https://orcid.org/0000-0001-5430-0816)
- Peter W. Stacpoole (ORCID: https://orcid.org/0000-0003-0680-5881)
- Anastasia V. Shindyapina (ORCID: https://orcid.org/0000-0002-7336-3086)
- Martin S. Denzel (ORCID: https://orcid.org/0000-0002-5691-3349)
- Brian N. Finck (ORCID: https://orcid.org/0000-0001-5411-3674)
- Andrzej T. Gałecki (ORCID: https://orcid.org/0000-0003-1542-4001)
- Navasuja Kumar (ORCID: https://orcid.org/0000-0003-0486-428X)
- Elizabeth Fernández
Institutions
- Brigham and Women's Hospital (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- The University of Texas at San Antonio Health Science Center (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- Bay Institute (US)
- Granta Design (United Kingdom) (GB)
- Michigan Medicine (US)
- Jackson Laboratory (US)
- Metabolic Solutions Development Company (United States) (US)
- Institute on Aging (US)
- South Texas Veterans Health Care System (US)
- Integrative Health Technologies (United States) (US)
- Max Planck Institute for Biology of Ageing (DE)
- Imperial College London (GB)
- Kalamazoo College (US)
- Florida College (US)
Publication Details
- Journal
- GeroScience
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1007/s11357-025-01881-6
- Citations
- 1
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.95