Differential Encoding of Odor and Place in the Mouse Piriform and Entorhinal Cortex

The integration of olfactory and spatial information is critical for guiding animal behavior. The lateral entorhinal cortex (LEC) is reciprocally interconnected with cortical areas for olfaction and the hippocampus and thus ideally positioned to encode odor-place associations. Here, we used miniendoscopes to record neural activity in the mouse piriform cortex (PCx) and LEC. We show that in head-fixed mice, odor identity could be decoded from LEC ensembles but less accurately than from PCx. In male mice freely navigating a linear track, LEC ensemble activity at the odor ports was dominated by spatial information. Spatial position along the linear track could be decoded from LEC and PCx activity; however, PCx but not LEC exhibited strong behavior-driven modulation of positional information. Together, our data reveal that information about odor cues and spatial context is differentially encoded along the PCx-LEC axis.

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Publication Details

Journal
eNeuro
Published
2025-09-19
DOI
https://doi.org/10.1523/eneuro.0026-25.2025
Primary Topic
Olfactory and Sensory Function Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Differential Encoding of Odor and Place in the Mouse Piriform and Entorhinal Cortex

Shahab Rezaei‐Mazinani, Yaniv Ziv, Brice Bathellier, Alon Rubin et al.
eNeuro
Olfactory and Sensory Function Studies
article

Differential Encoding of Odor and Place in the Mouse Piriform and Entorhinal Cortex

Shahab Rezaei‐Mazinani, Yaniv Ziv, Brice Bathellier, Alon Rubin, Alexander Fleischmann, Keeley L. Baker, Wilson Mena, Yun Joo Yoo, Shaun Kohli
article en

Abstract

The integration of olfactory and spatial information is critical for guiding animal behavior. The lateral entorhinal cortex (LEC) is reciprocally interconnected with cortical areas for olfaction and the hippocampus and thus ideally positioned to encode odor-place associations. Here, we used miniendoscopes to record neural activity in the mouse piriform cortex (PCx) and LEC. We show that in head-fixed mice, odor identity could be decoded from LEC ensembles but less accurately than from PCx. In male mice freely navigating a linear track, LEC ensemble activity at the odor ports was dominated by spatial information. Spatial position along the linear track could be decoded from LEC and PCx activity; however, PCx but not LEC exhibited strong behavior-driven modulation of positional information. Together, our data reveal that information about odor cues and spatial context is differentially encoded along the PCx-LEC axis.

eNeuroVol. 12(10)
Centre National de la Recherche Scientifique (FR), Allen Institute for Brain Science (US), Inserm (FR), Institut Pasteur (FR), Université Paris Cité (FR), Université Paris Sciences et Lettres (FR), Brown University (US), Mines Saint-Étienne (FR), Assistance Publique – Hôpitaux de Paris (FR), Centre Interdisciplinaire de Recherche en Biologie (FR), Centre of Biomedical Research (IN), Weizmann Institute of Science (IL)
National Institutes of Health, NIH Office of the Director, National Institute on Deafness and Other Communication Disorders
Openalex Percentile: Top 75%
Olfactory and Sensory Function Studies
DOIOpen Access PDFOpenAlex
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