Monitoring and risk of hepatitis B reactivation and hepatitis flare during tenofovir interruption among people with HIV and hepatitis B
In this large US cohort of people with HIV and HBV, tenofovir interruptions were common and HBV monitoring was sub-optimal. HBV reactivation rates were highest among the high-risk group, but much lower among the moderate-risk and low-risk groups. However, some reactivations were likely missed due to low monitoring frequency. Primary and HIV care providers must incorporate HBV monitoring in their standard of care and proceed with caution if considering a tenofovir interruption for people with HIV and HBV.
Authors
- Catherine Frenette (ORCID: https://orcid.org/0000-0002-2245-8173)
- Karam Mounzer (ORCID: https://orcid.org/0000-0001-8537-7103)
- Jennifer S Fusco (ORCID: https://orcid.org/0000-0003-1556-811X)
- Michael Wohlfeiler
- Travis Lim (ORCID: https://orcid.org/0000-0003-1662-7329)
- Leland J. Yee (ORCID: https://orcid.org/0000-0002-0369-5878)
- Douglas T. Dieterich (ORCID: https://orcid.org/0000-0001-7786-8594)
- Joshua Gruber
- Gerald Pierone (ORCID: https://orcid.org/0000-0003-0159-7243)
- Laurence Brunet (ORCID: https://orcid.org/0000-0001-8467-4835)
- Megan S. Dunbar (ORCID: https://orcid.org/0000-0001-9250-5126)
- Gregory Fusco (ORCID: https://orcid.org/0000-0002-6834-784X)
- Ricky K Hsu
Institutions
- AIDS Healthcare Foundation (US)
- NYU Langone Health (US)
- Oyster Point Family Health Center (US)
- Gilead Sciences (United States) (US)
- Dayforce (United States) (US)
- Philadelphia Fight (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- AIDS
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1097/qad.0000000000004353
- Citations
- 3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06