Curcumins‐Loaded ZIF‐8 Nanoparticles‐Embedded Transdermal Polymeric Patches Increase Apoptosis and Reduce Necrosis in a Dose‐Dependent Manner in MCF‐7 Cells
ABSTRACT Curcumin(Cur)‐loaded zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles (Cur@ZIF‐8 NPs) were produced to increase the anticancer activity of Cur. Cur@ZIF‐8 NPs were embedded in polycaprolactone (PCL) fibers as transdermal polymeric patches via a pressured gyration (PG) method to provide controlled release. Cur@ZIF‐8 NPs and Cur@ZIF‐8 NPs‐embedded PCL fibers were characterized for physical, chemical, mechanical, and thermal properties, also biological activities were examined with in vitro tests. Cur@ZIF‐8 NPs were produced homogeneously with a size of ∼200 nm and a zeta potential of ∼−19 mV. Cur had better stability inside Cur@ZIF‐8 NPs than its powder form. Cur@ZIF‐8 NPs were successfully loaded in PCL fibers with a size of ∼7 µm, and Cur@ZIF‐8 NPs were dispersed amorphously in fibers. Cur was released in a controlled manner, and its efficiency was increased in the acidic microenvironment that is characteristic of cancer. Cur@ZIF‐8 NPs have more bioavailability than powdered Cur and can penetrate the cells to deliver their anticancer effects on MCF‐7 human breast cancer cells. Cur@ZIF‐8 NPs‐embedded transdermal polymeric patches promote apoptosis in MCF‐7 cells by reducing necrosis, particularly under acidic conditions. This work presents a release system with synergistic anticancer effects, offering a novel approach for Cur's clinical application in breast cancer through enhanced targeting.
Authors
- Muhammet Emin Çam (ORCID: https://orcid.org/0000-0001-5398-6801)
- Mohan J. Edirisinghe (ORCID: https://orcid.org/0000-0001-8258-7914)
- Özgür Duygulu (ORCID: https://orcid.org/0000-0001-8646-0363)
- Müge Sennaroğlu Bostan (ORCID: https://orcid.org/0000-0002-2909-689X)
- Ece Güler (ORCID: https://orcid.org/0000-0002-0639-5029)
- Ayşe Mine Yılmaz (ORCID: https://orcid.org/0000-0003-0802-523X)
- Humeysa Kiyak‐Kirmaci (ORCID: https://orcid.org/0000-0003-2574-4762)
- Ziya Engin Erkmen (ORCID: https://orcid.org/0000-0002-1658-7040)
- Fernando Mendes (ORCID: https://orcid.org/0000-0002-5205-8939)
- Diana Martins (ORCID: https://orcid.org/0000-0002-1457-8992)
- Mehmet S. Eroğlu (ORCID: https://orcid.org/0000-0003-0742-6162)
- Saliha Aydın (ORCID: https://orcid.org/0000-0001-7499-1028)
- Humeyra Betul Yekeler (ORCID: https://orcid.org/0000-0002-1904-5706)
- Ayse Beyza Kayaci
- Zeynep Gurer
Institutions
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TR)
- Polytechnic Institute of Coimbra (PT)
- Istanbul Kent University (TR)
- TÜBİTAK Marmara Research Center (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- European Steel Association (BE)
- Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic (TR)
- Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi (TR)
- University College London (GB)
- Marmara University (TR)
- University of Coimbra (PT)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Nano Select
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1002/nano.70048
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu