Recurrent and Refractory Ewing Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium
This review highlights evolving therapeutic directions in R/R EwS, with increased emphasis on targeted therapies and immunotherapies. Despite pandemic-related delays, trials have progressed in exploring novel targets, including EWSR1::FLI1 oncogenic fusion and DNA repair pathways. These findings underscore ongoing global efforts to address critical unmet needs in EwS treatment, offering a foundation for future trial designs, especially international, randomized phase-II trials across all age ranges.
Authors
- Martin G. McCabe (ORCID: https://orcid.org/0000-0002-5138-0707)
- Thomas G. P. Grünewald (ORCID: https://orcid.org/0000-0003-0920-7377)
- Pan Pantziarka (ORCID: https://orcid.org/0000-0002-4676-7835)
- Christina Linder‐Stragliotto (ORCID: https://orcid.org/0009-0002-1247-7028)
- Pablo Berlanga (ORCID: https://orcid.org/0000-0003-1110-7789)
- Susanne A. Gatz (ORCID: https://orcid.org/0000-0002-6438-9778)
- Sandra J. Strauss (ORCID: https://orcid.org/0000-0001-8328-0260)
- Nathalie Gaspar (ORCID: https://orcid.org/0000-0002-1827-8903)
- A. Felix (ORCID: https://orcid.org/0000-0002-6034-6869)
- Mehdi Brahmi (ORCID: https://orcid.org/0000-0001-9904-166X)
- Antonio Juan Ribelles (ORCID: https://orcid.org/0000-0002-2662-7632)
- Emanuela Palmerini (ORCID: https://orcid.org/0000-0003-3406-6705)
- Didier Surdez (ORCID: https://orcid.org/0000-0002-7118-7859)
- Nuria Benavent (ORCID: https://orcid.org/0000-0002-5604-8818)
- Josep Escrivá-Fernández (ORCID: https://orcid.org/0000-0002-1598-0633)
Institutions
- University of Miami (US)
- German Cancer Research Center (DE)
- University of Zurich (CH)
- Heidelberg University (DE)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- University Hospital Heidelberg (DE)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- Hospital Universitari i Politècnic La Fe (ES)
- King George Hospital (GB)
- Centre Léon Bérard (FR)
- National Center for Tumor Diseases (DE)
- Hopp Children's Cancer Center Heidelberg (DE)
- Istituto Ortopedico Rizzoli (IT)
- Leitat Technological Center (ES)
- Universitätsklinik Balgrist (CH)
- Cancer Research UK Manchester Institute (GB)
- The Christie NHS Foundation Trust (GB)
- Centre Hospitalier Universitaire de Martinique (MQ)
- CRUK Lung Cancer Centre of Excellence (GB)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- Sylvester Comprehensive Cancer Center (US)
- Instituto de Investigación Sanitaria La Fe (ES)
- Anticancer Fund (BE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University College London (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1200/po-25-00377
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52