Expanded CD4+CD57+ T-large granular lymphocytes: A diagnostic pitfall in blood staging of mycosis fungoides/Sézary syndrome
The presence of expanded T-LGL populations in blood can confound accurate staging of MF/SS, potentially leading to misclassification and ineffective or unnecessary treatment. These cases exemplify how comprehensive molecular and immunophenotypic profiling, including multicolor flow cytometry and T-cell receptor comparisons, along with morphologic evaluation of blood ensure accurate disease assessment to inform better clinical decision-making in MF/SS.
Authors
- Dahui Qin (ORCID: https://orcid.org/0000-0001-9618-5836)
- Christopher B. Ryder (ORCID: https://orcid.org/0000-0002-4600-2963)
- Lubomir Sokol
- Oluwatobi Ozoya (ORCID: https://orcid.org/0000-0002-1245-3838)
- Yumeng Zhang (ORCID: https://orcid.org/0000-0003-1942-1780)
- Frank Glass
Institutions
- Moffitt Cancer Center (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1093/ajcp/aqaf097
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00