HIF1A regulates follicular atresia through O-GlcNAcylation-mediated VEZF1/ET-1/FOXO1/BAX signaling in porcine granulosa cells
Overall, our study elucidates a novel molecular mechanism by which HIF1A deficiency modulates follicular atresia through O-GlcNAcylation-mediated VEZF1 expression. These results not only clarify the molecular mechanism of ovarian follicular development under hypoxic conditions but also offer potential targets for improving follicular selection efficiency in pig breeding.
Authors
- Wenbin Bao (ORCID: https://orcid.org/0000-0001-5486-2253)
- Yi Liu (ORCID: https://orcid.org/0000-0003-2990-5738)
- Zhengchang Wu (ORCID: https://orcid.org/0000-0003-2198-5227)
- Aiwen Jiang
- Shenglong Wu (ORCID: https://orcid.org/0000-0003-3876-9483)
- Jialong Li (ORCID: https://orcid.org/0000-0003-4539-0594)
- Haifei Wang (ORCID: https://orcid.org/0000-0003-2424-9743)
- Luyao Wang (ORCID: https://orcid.org/0000-0002-5274-7857)
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1186/s40104-025-01263-0
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Agricultural University