Incidence of Anti-Drug Antibody Development in Older Adults with Inflammatory Bowel Disease Treated with Tumor Necrosis Factor Alpha Inhibitors: A Large Multicenter Cohort Study
Older adults are more likely to develop ADAs against TNFi compared to younger adults. Proactive TDM may be considered in this population for early identification of ADAs and subtherapeutic trough levels, enabling timely dose escalation or treatment modification.
Authors
- Chetan Ambastha
- Mark Lazarev (ORCID: https://orcid.org/0000-0002-5517-3588)
- Laura Maas (ORCID: https://orcid.org/0000-0002-2401-2685)
- Andrew Roney (ORCID: https://orcid.org/0000-0002-5812-7819)
- Alexandra C. Greb (ORCID: https://orcid.org/0000-0003-0667-1844)
- Mahesh Krishna (ORCID: https://orcid.org/0000-0001-9762-5717)
- Kian Keyashian (ORCID: https://orcid.org/0000-0002-5333-2514)
- Eric Moughames (ORCID: https://orcid.org/0000-0001-8668-9846)
- Andrew Ho (ORCID: https://orcid.org/0000-0003-1287-9844)
- Alyssa Parian (ORCID: https://orcid.org/0000-0001-9995-7942)
- Maricela Rangel-Garcia
- Berkeley N. Limketkai (ORCID: https://orcid.org/0000-0003-2714-6934)
- David Limsui
- Jenny Sauk (ORCID: https://orcid.org/0000-0001-6731-8193)
- Sunhee Park
- Christopher Chang (ORCID: https://orcid.org/0000-0002-3290-3306)
- Devin Patel (ORCID: https://orcid.org/0000-0002-9764-5870)
- Andrew Suchan
- Sowmya Sharma (ORCID: https://orcid.org/0000-0002-1067-6587)
- Reezwana Chowdhury
- Spencer Frost
Institutions
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- Johns Hopkins Medicine (US)
- Santa Clara Valley Medical Center (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-07-18
- DOI
- https://doi.org/10.1093/ibd/izaf170
- Primary Topic
- Biosimilars and Bioanalytical Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00