Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program
Genetic variants associated with hypoglycemia risk in individuals with medication-treated diabetes have not been evaluated genome-wide. The specific question we asked was whether common genetic variants are associated with hypoglycemia among individuals with diabetes treated with glucose-lowering medications. We found four genomic loci were associated with hypoglycemia in a genome-wide association study. One locus-on chromosome 6-was associated with hypoglycemia only in individuals with likely type 1 diabetes, and two loci-on chromosome 2 and chromosome 6-were associated with hypoglycemia only in the context of treatment with sulfonylureas (chromosome 2) or with insulin (chromosome 6). Genetic variants may help identify individuals with diabetes at increased hypoglycemia risk, but additional study is needed to address the clinical utility of genetic data to inform hypoglycemia risk.
Authors
- Aaron Leong
- Peter D. Reaven (ORCID: https://orcid.org/0000-0001-8923-6690)
- Sridharan Raghavan (ORCID: https://orcid.org/0000-0003-0643-4873)
- Qin Hui
- Jin Zhou (ORCID: https://orcid.org/0000-0002-5534-1123)
- Brian Charest
- James B. Meigs (ORCID: https://orcid.org/0000-0002-2439-2657)
- Yan V. Sun (ORCID: https://orcid.org/0000-0002-2838-1824)
- Elizabeth Litkowski (ORCID: https://orcid.org/0000-0002-7079-696X)
- A. E. Jensen (ORCID: https://orcid.org/0000-0001-8807-428X)
- Hua‐Chang Chen (ORCID: https://orcid.org/0000-0003-0497-2483)
- Adriana M. Hung (ORCID: https://orcid.org/0000-0002-3203-1608)
- Ethan M. Lange (ORCID: https://orcid.org/0000-0001-7075-4287)
- Lawrence S. Phillips (ORCID: https://orcid.org/0000-0002-6542-8046)
- Mary K. Rhee (ORCID: https://orcid.org/0000-0002-0747-1476)
- Zeyuan Wang
- Leslie A. Lange (ORCID: https://orcid.org/0000-0002-8077-4975)
Institutions
- Emory University (US)
- University of California, Los Angeles (US)
- University of Michigan (US)
- Veterans Health Administration (US)
- VA Boston Healthcare System (US)
- Massachusetts General Hospital (US)
- VA Tennessee Valley Healthcare System (US)
- Phoenix VA Health Care System (US)
- Michigan Medicine (US)
- VA Eastern Colorado Health Care System (US)
- Department of Veterans Affairs (AU)
- Carl T. Hayden Veterans Affairs Medical Center (US)
- Atlanta VA Medical Center (US)
- University of Colorado Anschutz Medical Campus (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-09-19
- DOI
- https://doi.org/10.2337/db25-0304
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00