The association between bone turnover biomarkers and the severity of white matter hyperintensities
β-CTX was independently linked to WMH/PWMH severity, and PTH to DWMH severity, pointing to a possible bone-cerebrovascular axis. Larger prospective and interventional studies should confirm these markers as potential CSVD biomarkers and treatment targets.
Authors
- Hongtao Hu (ORCID: https://orcid.org/0000-0001-8261-7458)
- Xiaofan You
- Yufeng Ge (ORCID: https://orcid.org/0000-0002-4968-6520)
- Lin Lei
- Ying Li (ORCID: https://orcid.org/0000-0002-2693-6056)
- Qian You (ORCID: https://orcid.org/0000-0002-9110-9460)
- Xufeng Chen (ORCID: https://orcid.org/0000-0001-9870-4820)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fneur.2025.1624505
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00