The effect of methadone and ketamine on quality of recovery in patients undergoing laparoscopic cholecystectomy: a prospective cohort study
Although the combination of methadone and ketamine showed a slight increase in QoR40 scores at 24 h postoperatively, the observed difference between the groups was not clinically significant. Moreover, the absence of a reduction in postoperative pain intensity and similar perioperative opioid consumption between the groups further support the hypothesis that small, isolated doses of ketamine may not be effective in improving recovery quality compared with methadone alone.
Authors
- Sérgio M. Pereira (ORCID: https://orcid.org/0000-0003-3790-7506)
- Ana Clara Mourão Barreto
- Leopoldo Muniz da Silva (ORCID: https://orcid.org/0000-0003-4703-0832)
- Rafael Souza Fava Nersessian (ORCID: https://orcid.org/0000-0002-8786-9475)
- Helidea de Oliveira Lima (ORCID: https://orcid.org/0009-0009-2107-1266)
- Saullo Queiroz Silveira (ORCID: https://orcid.org/0000-0002-6110-5493)
- Gabriel Silva dos Anjos (ORCID: https://orcid.org/0009-0006-0182-904X)
- Matheus de Alencar Arraes (ORCID: https://orcid.org/0009-0002-3253-0762)
Institutions
- University of Toronto (CA)
- D’Or Institute for Research and Education (BR)
- Hospital São Paulo (BR)
Publication Details
- Journal
- Sao Paulo Medical Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/1516-3180.2024.0193.r2.18062025
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00