Obeticholic acid prevents cyclophosphamide-induced placental injury via SIRT1 and TLR4/NF-κB pathways
Accordingly, these findings suggest that OCA protects CP-induced placental injury by modulating TLR4/Myd88/NF-κB; SIRT1-dependant signaling pathways.
Authors
- Asmaa Mohamed Mahmoud Ali (ORCID: https://orcid.org/0000-0002-7421-5085)
- Ahmed Mohsen Abdelhakeem
- Mina Ezzat Attya
- Walaa Yehia Abdelzaher (ORCID: https://orcid.org/0000-0001-6511-1797)
- Hanaa Mohamed Khalaf (ORCID: https://orcid.org/0000-0003-2102-1671)
- Sara M. Ahmed (ORCID: https://orcid.org/0000-0001-8572-3168)
- Marwa Hassan (ORCID: https://orcid.org/0009-0001-5129-6361)
- Alaa Mohamed (ORCID: https://orcid.org/0000-0001-5193-3319)
- Mohammed Khairy (ORCID: https://orcid.org/0000-0003-4060-0804)
- Shereen S. Gaber
Institutions
- Minia University (EG)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1186/s40360-025-00986-0
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund