Is the use of vaginal progesterone a factor in pregnant women diagnosed with gestational diabetes mellitus?

The findings suggest that the use of vaginal progesterone may increase the risk of gestational diabetes mellitus, and the risk appears to rise with the duration of progesterone use. It is important to consider that patients on prolonged vaginal progesterone, particularly those started early in pregnancy, may be at increased risk of diabetes. Therefore, it may be advisable to repeat the oral glucose tolerance test performed at 24-28 weeks in the following weeks.