Abstract A088: Exploring the impacts of ethnic enclaves on female screenable cancers among Chinese and Vietnamese Americans in southern California

Abstract Introduction: Breast (BC) and cervical cancer (CC) are 2 screenable cancers, yet both are leading causes of cancer incidence and mortality among Asian American (AA) women. BC and CC risks and outcomes among AA women may be influenced by residing in ethnic enclaves, as many Asian subgroups tend to live in ethnic enclaves upon immigrating to the United States. The relationship between ethnic enclaves and cancer has not been extensively studied in AA, with results being inconclusive. This could be attributable to the lack of disaggregation of AA subgroups. Given the cultural and socioeconomic differences between AA subgroups, it is important to disaggregate AA subgroups to be able to better understand the cancer burden within specific AA subgroups. We aimed to explore the association between residing in ethnic enclaves with late-stage screenable cancers (BC and CC combined) risk and overall survival among Chinese and Vietnamese Americans. Methods: We identified Chinese and Vietnamese women diagnosed with either screenable cancers in southern California between 2011 and 2020 using the California Cancer Registry. We defined the ethnic enclave for the 2 AA subgroups by evaluating the geospatial distribution of screenable cancers cases using a cancer kernel density surface. Logistic regressions evaluated the association between ethnic enclave and late-stage screenable cancers risk. Five-year observed survival rates were calculated and log rank tests determined whether survival rates differed by enclave living status. Cox proportional hazards regressions assessed the association between ethnic enclave and overall survival. All analyses were stratified by the 2 AA subgroups. Results: Our sample contained 5,456 Chinese Americans and 2,628 Vietnamese Americans with screenable cancers. We did not find an association between residing in ethnic enclaves and late-stage screenable cancers among Chinese (p=0.13) and Vietnamese Americans (p=0.30). However, survival outcomes differed by enclave living status among Chinese Americans, with Chinese individuals diagnosed with a screenable cancer and living inside the enclave having lower 5-year observed survival rates compared to their counterparts living outside the enclave (p=0.02). Conclusions: We found that residing in ethnic enclaves was associated with lower survival for Chinese Americans, but not for Vietnamese Americans. We did not find an association between ethnic enclaves and late-stage screenable cancers for either AA subgroup. This indicates that ethnic enclaves may impact cancer outcomes more than late-stage risk, as well as impact certain AA subgroups more than others. Future studies should aim to evaluate the association between ethnic enclaves and cancer outcomes among specific AA subgroups to develop and deliver the appropriate intervention. Citation Format: Michelle Tran, Sue E. Kim, Kali Zhou, Lihua Liu, Kimberly A. Miller, Myles Cockburn. Exploring the impacts of ethnic enclaves on female screenable cancers among Chinese and Vietnamese Americans in southern California [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr A088.