Abstract C143: Prevalence and progression of pre-invasive cervical lesions during pregnancy at the University of Ilorin Teaching Hospital, Ilorin, Nigeria

Abstract Introduction: This study aimed to investigate the prevalence of pre-invasive cervical lesions during pregnancy, identify the types of lesions, and determine the impact of pregnancy on their progression. Methodology: A prospective observational study was conducted using Papanicolaou smear at the University of Ilorin Teaching Hospital in Ilorin, Nigeria. Simple random sampling was employed to select participants. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) software, version 26. Results: Two hundred and seven women took part in the study, with an average age of 30.10 ± 5.49 years. A normal Pap smear was recorded in 93.2% of participants, while abnormal smears were detected in 14 (6.8%). Among the abnormal smears detected during pregnancy, ASC-US was found in 9 (64.3%), ASC-H in 3 (21.4%), and LSIL in 2 (14.3%). At the second screening, conducted six weeks postpartum, one (11.1%) of the women with ASC-US progressed to LSIL, and one with LSIL progressed to HSIL (50.0%). Two (14.3%) women with abnormal smears were lost to follow-up. The lesions in the remaining women had regressed and reverted to normal. Women diagnosed with HSIL underwent colposcopic evaluation in the Colposcopy Unit, while those whose lesions had regressed were advised to continue routine screening under the hospital’s cervical screening program. Conclusions: Cervical smear screening during pregnancy is a valuable tool for detecting pre-invasive cervical lesions. It is essential to recognize that these lesions may progress during pregnancy, warranting repeat testing six weeks postpartum and appropriate management. Furthermore, increasing public awareness about this issue is of paramount importance. Citation Format: Adegboyega Adisa. Fawole, Olakunle Emmanuel. Ogunjide, Kikelomo Temilola. Adesina, Olatunde Kazeem. Ibrahim, Olubusayo Olufunke. Areo, Abiodun Sulaiman. Adeniran. Prevalence and progression of pre-invasive cervical lesions during pregnancy at the University of Ilorin Teaching Hospital, Ilorin, Nigeria [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr C143.