Abstract A067: Multilevel determinants of health behavior participation among Hispanic/Latino men with prostate cancer on androgen deprivation therapy: A cross-sectional survey

Abstract BACKGROUND: Hispanic/Latino (H/L) patients with prostate cancer (PCa) are at an increased risk of developing side effects related to androgen deprivation therapy (ADT). While diet and exercise can reduce these toxicities, little is known about factors influencing their engagement in health-promoting behaviors. METHODS: We developed a survey to examine sociodemographic characteristics, exercise/dietary habits, motivation for change, and barriers to participate in lifestyle interventions. We surveyed patients with PCa who self-identified as H/L ethnicity, treated at UCSD, and who were either previously or currently on ADT at the time of the survey. Questionnaires were administered in Spanish or English, either in person or by telephone, using interpreter services based on patient preference. RESULTS: Sixty one patients (median age 66 years) completed the survey with an 88% response rate. Most patients were of Mexican descent (85%), born outside the U.S. (72%), had public health insurance (51%), resided in disadvantaged neighborhoods (54%) based on the Area Deprivation Index (ADI), from H/L ethnic enclaves (64%), and were primarily Spanish speakers (51%), with 36% reporting limited English proficiency. About half (49%) reported household financial distress, yet 92% felt supported by their community or family during PCa diagnosis. At the time of the survey, 85% of patients were on ADT and 68% had distant metastasis. Most had a BMI >= 30 kg/m2 (52%), diabetes (51%), and 66% had a history of coronary artery disease (CAD) or a high-risk atherosclerotic cardiovascular disease (ASCVD) score of >= 20%. Most patients (51%) reported limited dietary monitoring and 71% reported less than 50 min/week of moderate-intensity exercise, with 41% not engaging in any moderate exercise. However, most (82%) showed interest in joining a community exercise program. Participation incentives included family involvement (73%), other H/L participants (77%), Spanish-speaking staff (86%), and a shorter driving distance. Neighborhood disadvantage (ADI quintile > 3) was linked to higher odds of CAD or high ASCVD risk (OR 5.4, p = 0.02), de novo metastatic PCa (OR >10, p < 0.01), lower clinical trial participation (OR 0.08, p < 0.01), self-reported physical inactivity (OR 4.6, p = 0.01), financial distress (OR 5, p < 0.01), and time toxicity (OR 4.6, p < 0.01). CONCLUSIONS: We report that H/L patients with PCa on ADT face substantial cardiometabolic risk factor burden and limited access to health-promoting activities due to socioeconomic and cultural barriers. Despite low physical activity, patients expressed motivation to improve health behaviors, when provided with incentives, underscoring the need for tailored interventions to mitigate ADT toxicity. These findings will inform the design of an interventional study that examines the impact of a combined group exercise and nutrition counseling intervention on physical fitness and cardiovascular health among H/L men with PCa on ADT. Citation Format: Sharon H. Choi, Frances Ramos, Bryanna Chavez, Kristine Ly, Samuel Pena, Yu-Wei Chen, J. Michael Randall, Tyler Stewart, Fred Millard, James Murphy, Noe Crespo, Soo Park, Brent Rose, Aditya Bagrodia, Elena Martinez, Rana R. McKay. Multilevel determinants of health behavior participation among Hispanic/Latino men with prostate cancer on androgen deprivation therapy: A cross-sectional survey [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr A067.