An endoplasmic reticulum-targeted NIR-II type I AIE photosensitiser for triggering pyroptosis
In this work, we developed an endoplasmic reticulum-targeted NIR-II photosensitizer (TI-ER), which exhibits type I ROS generation and photothermal capabilities. After formulation into nanoparticles (NPs), TI-ER NPs were efficiently internalized by cancer cells and induced pyroptosis under 635 nm laser irradiation, efficiently ablating both cancer cells and multicellular tumor spheroids.
Authors
- Lijin Yang (ORCID: https://orcid.org/0000-0003-3787-6658)
- Bingbing He (ORCID: https://orcid.org/0000-0002-9790-8087)
- Dongxiu Li
- Na Zhao (ORCID: https://orcid.org/0000-0003-1412-3135)
- Chenyang Lei (ORCID: https://orcid.org/0000-0002-5397-4541)
- Nan Li (ORCID: https://orcid.org/0000-0003-4231-8853)
- Xinyu Li (ORCID: https://orcid.org/0000-0003-2314-4480)
Institutions
- Shaanxi Normal University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04652a
- Citations
- 2
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 1.61