Cs <sub>2</sub> CO <sub>3</sub> ‐Mediated [3 + 3] Cyclization of 2‐Amino‐4 <i>H</i> ‐chromen‐4‐ones and Benzylidene Meldrum's Acids: Access to Chromeno[2,3‐ <i>b</i> ]pyridinones
Abstract An [3 + 3] annulation of 2‐aminochromen‐4‐ones with substituted benzylidene Meldrum's acids has been developed. This reaction included a sequential intermolecular Michael addition/intramolecular nucleophilic addition/ring opening of Meldrum's acid/ removal of acetone/decarboxylation sequence, which possessed excellent step in a single operation for direct generating to substituted chromeno[2,3‐ b ]pyridinones from readily available substrates.
Authors
- Cunde Wang (ORCID: https://orcid.org/0000-0001-5561-979X)
- Jiaman Lv
- Ziyang Zhang (ORCID: https://orcid.org/0000-0001-5870-704X)
- Lizhong Wang (ORCID: https://orcid.org/0000-0003-1980-4730)
- Jiaming Liu (ORCID: https://orcid.org/0000-0002-4960-8813)
- Wen-Yan Zhou
Institutions
- Taizhou Vocational and Technical College (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1002/ajoc.70205
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00