Endothelial–Pericyte Interactions Regulate Angiogenesis Via VEGFR2 Signaling During Retinal Development and Disease
Our findings uncover a novel mechanism by which VEGFR2 signaling is regulated through endothelial-pericyte interactions, promoting pericyte migration and strengthening endothelial barrier function. These results suggest a pathway that could be harnessed to support the growth of functional and mature microvasculature in ocular microvascular diseases and tissue regeneration overall.
Authors
- Ying-Yu Lin (ORCID: https://orcid.org/0000-0002-9153-5814)
- Emily Warren (ORCID: https://orcid.org/0000-0001-5839-0222)
- Sharon Gerecht (ORCID: https://orcid.org/0000-0002-8542-4835)
- Bria Macklin
- Laura Ramírez
Institutions
- Johns Hopkins University (US)
- Duke University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1167/iovs.66.12.45
- Citations
- 1
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81