Small Extracellular Vesicle Treatment of Trabecular Meshwork Fibrosis: 2D/3D In Vitro and In Vivo Analyses
hBMMSC sEVs significantly attenuate TGFβ2-induced TM fibrosis via both protein expression and morphological changes. In addition, hBMMSC sEVs have therapeutic potential in alleviating the TGFβ2-induced increase in IOP linked to TM fibrosis.
Authors
- Caiqing Wu
- Yufan Jiang (ORCID: https://orcid.org/0009-0005-9289-1529)
- Lixia Lin (ORCID: https://orcid.org/0000-0001-5220-1427)
- Minbin Yu
- Y. Zhang (ORCID: https://orcid.org/0000-0002-2361-377X)
- Xiaofeng Zhu
- Yangfan Yang
- Yutong Che
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1167/iovs.66.12.48
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47