Association Between Pigmentation Heritage and Susceptibility to Experimentally Induced Myopia: Crossbreeding Insights From Albino and Pigmented Guinea Pigs
Crossbreeding improved retinal function and choroidal morphology, while preserving susceptibility to FDM, suggesting a partial restoration of myopia-inducible mechanisms inherited from the albino lineage. These findings support the value of the crossbred model for investigating retinal and choroidal regulation in myopia.
Authors
- Leopold F. Schmetterer (ORCID: https://orcid.org/0000-0002-7189-1707)
- Myo Thu Khine
- William Myles (ORCID: https://orcid.org/0000-0002-4032-4072)
- Veluchamy A. Barathi (ORCID: https://orcid.org/0000-0002-6477-9784)
- Quan V. Hoang (ORCID: https://orcid.org/0000-0002-5486-9292)
- James Koh (ORCID: https://orcid.org/0000-0001-6853-8606)
- Yee Shan Dan (ORCID: https://orcid.org/0000-0001-9601-4105)
- Liqin Jiang (ORCID: https://orcid.org/0000-0003-2750-0278)
- S Seah
Institutions
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Singapore National Eye Center (SG)
- Fondation Ophtalmologique Adolphe de Rothschild (FR)
- Medical University of Vienna (AT)
- Columbia University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1167/iovs.66.12.47
- Citations
- 1
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Lee Foundation
- Nanyang Technological University
- Medical Research Council
- National Medical Research Council
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Biomedical Research Council