Targeting RPE Senescence Via Suppressing IL-6/IL-6R Signaling for Treating Retinal Degenerative Diseases
IL-6 and IL-6R/STAT3 signaling played an essential role in RPE senescence, and tocilizumab presents a translational opportunity in treating retinal degenerative diseases.
Authors
- Xiaojing Lin (ORCID: https://orcid.org/0000-0003-3015-3481)
- Ziqi Yang (ORCID: https://orcid.org/0000-0001-5890-2873)
- Hong Zhou (ORCID: https://orcid.org/0000-0002-5946-9183)
- Tian Zhou (ORCID: https://orcid.org/0000-0002-7871-8798)
- Xialin Liu (ORCID: https://orcid.org/0000-0003-2086-5805)
- Huiyi Xu (ORCID: https://orcid.org/0000-0001-7955-3772)
- Biyan Ni (ORCID: https://orcid.org/0000-0003-0482-3816)
- Chang He (ORCID: https://orcid.org/0000-0003-1178-5950)
- Yang Zhou (ORCID: https://orcid.org/0000-0001-9273-0489)
- Yi Wei (ORCID: https://orcid.org/0000-0002-7310-5634)
- Shiya Lin
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1167/iovs.66.12.44
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00