Beyond DSM subtypes: Neuropsychological evidence against functional distinctions in childhood ADHD

The diagnostic subtypes of Attention-Deficit/Hyperactivity Disorder (ADHD) described in the DSM-5 remain widely used in clinical practice despite increasing evidence of their instability and questionable neurocognitive validity. This study examined whether the inattentive, hyperactive/impulsive, and combined presentations correspond to distinct cognitive profiles in school-aged children with ADHD. A total of 114 children aged 7-12 years with DSM-5 ADHD diagnoses were assessed with a standardized neuropsychological battery targeting executive functions, working memory, verbal fluency, and sustained attention. Subtypes were classified with the parent-report SNAP-IV. Exclusionary comorbidities were ruled out via structured interviews and a DSM-based screening tool. Between-group comparisons employed Kruskal-Wallis tests and Bayesian ANOVAs, and a k-means cluster analysis identified empirical cognitive profiles independent of subtype labels. Results showed no significant differences in 14 of 15 measures (all <i>p</i> > 0.05). Bayesian analyses provided substantial support for similarity (BF<sub>10</sub> < 0.33; <i>η</i><sup>2</sup> ≤ 0.06), with only phonological fluency showing a modest group effect (H = 9.52, <i>p</i> = 0.009; BF<sub>10</sub> = 3.89; <i>η</i><sup>2</sup> = 0.084). Cluster analysis yielded two stable profiles (low vs. average-high performance) unrelated to DSM-5 subtypes. These findings challenge the clinical utility of symptom-based subtyping in ADHD and support dimensional, performance-based classification models to guide assessment and individualized intervention.

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Publication Details

Journal
Applied Neuropsychology Child
Published
2025-09-18
DOI
https://doi.org/10.1080/21622965.2025.2556429
Citations
2
Primary Topic
Attention Deficit Hyperactivity Disorder
Type
article
Field-Weighted Citation Impact
2.94
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article

Beyond DSM subtypes: Neuropsychological evidence against functional distinctions in childhood ADHD

José Heredia‐Jimenez, Emilio Díaz-Moreno, Manuel Escabias
2 citations
Applied Neuropsychology Child
Attention Deficit Hyperactivity Disorder
2.94
article

Beyond DSM subtypes: Neuropsychological evidence against functional distinctions in childhood ADHD

José Heredia‐Jimenez, Emilio Díaz-Moreno, Manuel Escabias
article en
2 citations

Abstract

The diagnostic subtypes of Attention-Deficit/Hyperactivity Disorder (ADHD) described in the DSM-5 remain widely used in clinical practice despite increasing evidence of their instability and questionable neurocognitive validity. This study examined whether the inattentive, hyperactive/impulsive, and combined presentations correspond to distinct cognitive profiles in school-aged children with ADHD. A total of 114 children aged 7-12 years with DSM-5 ADHD diagnoses were assessed with a standardized neuropsychological battery targeting executive functions, working memory, verbal fluency, and sustained attention. Subtypes were classified with the parent-report SNAP-IV. Exclusionary comorbidities were ruled out via structured interviews and a DSM-based screening tool. Between-group comparisons employed Kruskal-Wallis tests and Bayesian ANOVAs, and a k-means cluster analysis identified empirical cognitive profiles independent of subtype labels. Results showed no significant differences in 14 of 15 measures (all <i>p</i> > 0.05). Bayesian analyses provided substantial support for similarity (BF<sub>10</sub> < 0.33; <i>η</i><sup>2</sup> ≤ 0.06), with only phonological fluency showing a modest group effect (H = 9.52, <i>p</i> = 0.009; BF<sub>10</sub> = 3.89; <i>η</i><sup>2</sup> = 0.084). Cluster analysis yielded two stable profiles (low vs. average-high performance) unrelated to DSM-5 subtypes. These findings challenge the clinical utility of symptom-based subtyping in ADHD and support dimensional, performance-based classification models to guide assessment and individualized intervention.

Applied Neuropsychology Child
Universidad de Granada (ES), Chicago Neuropsychology Group (US), Motion Control (United States) (US)
Openalex Percentile: Top 8%
Attention Deficit Hyperactivity Disorder
2.94
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Beyond DSM subtypes: Neuropsychological evidence against functional distinctions in childhood ADHD — José Heredia‐Jimenez, Emilio Díaz-Moreno, et al. · Applied Neuropsychology Child (2025) | TGRS Research Map | TGRS