Penicillin Disrupts Dental Mineralization in Rats: A Comparative Study With Tetracycline Highlighting Prenatal and Postnatal Risks
Penicillin at 100 mg/kg adversely affected enamel and dentin development, causing significant defects similar to those caused by tetracycline, although the severity and mechanisms may differ. Even at 50 mg/kg, penicillin disrupted enamel and dentin development, underscoring the clinical relevance of these findings and the need for caution when prescribing penicillin during pregnancy, even at lower doses, due to its potential to disrupt dental development.
Authors
- Morteza Banakar (ORCID: https://orcid.org/0000-0003-1715-0198)
- Fatemeh Mashhadiabbas (ORCID: https://orcid.org/0000-0002-8711-2843)
- Somayeh Kameli
- Amir Mohammad Sharafi
- Motahare Ahmadvand
- Sedigheh Mozafar
- Reza Omid (ORCID: https://orcid.org/0000-0001-8999-5670)
- Majid Mehran
Institutions
- Shahed University (IR)
- Shiraz University of Medical Sciences (IR)
- Islamic Azad University Dental Branch of Tehran (IR)
- Sina Hospital (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Saveetha University (IN)
Publication Details
- Journal
- Clinical and Experimental Dental Research
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1002/cre2.70225
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00