A Digital Measure of Eye Movements During Reading Sensitively Captures Oculomotor and Speech Dysfunction, Early Changes, and Disease Progression in Ataxias
Digital measures of eye movements are a promising approach for sensitively measuring ataxia in clinical trials (including early-stage disease) and may have utility in other neurodegenerative diseases affecting speech or ocular control. ANN NEUROL 2026;99:84-95.
Authors
- Brandon Oubre (ORCID: https://orcid.org/0000-0002-1807-4775)
- Radhika Manohar
- Anna C. Luddy (ORCID: https://orcid.org/0000-0002-2184-7687)
- Christopher D. Stephen (ORCID: https://orcid.org/0000-0002-4727-192X)
- Jeremy D. Schmahmann (ORCID: https://orcid.org/0000-0003-0706-5125)
- Siddharth M. Patel (ORCID: https://orcid.org/0000-0002-4637-4361)
- Faye X. Yang
- Anoopum S. Gupta (ORCID: https://orcid.org/0000-0002-8741-0621)
- Divya D. Kulkarni (ORCID: https://orcid.org/0000-0001-9772-4002)
- Lawrence T. White
- Nancy N. Soja
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1002/ana.78039
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91