A Solvent‐Free One‐Pot Synthesis of Ethyl 4‐Oxo‐3,4‐Dihydro Quinazoline‐2‐Carboxylates Utilizing <i>N</i> ‐(2‐Aminobenzoyl) Benzotriazoles

ABSTRACT A new solvent‐free one‐pot method for the synthesis of ethyl 4‐oxo‐3,4‐dihydroquinazoline‐2‐carboxylates using N ‐(2‐aminobenzoyl) benzotriazoles was developed. In this method, ethyl 4‐oxo‐3,4‐dihydroquinazoline‐2‐carboxylates were obtained in good yields (20%–85%) by the reaction of N ‐(2‐amino benzoyl) benzotriazoles with diethyl oxalate and ammonium acetate in the absence of solvent.

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Publication Details

Journal
Journal of Heterocyclic Chemistry
Published
2025-09-18
DOI
https://doi.org/10.1002/jhet.70088
Primary Topic
Quinazolinone synthesis and applications
Type
article
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article

A Solvent‐Free One‐Pot Synthesis of Ethyl 4‐Oxo‐3,4‐Dihydro Quinazoline‐2‐Carboxylates Utilizing N ‐(2‐Aminobenzoyl) Benzotriazoles

İlhami Çelik, Sultan Funda Ekti, Nasir Ahmad Heravi
Journal of Heterocyclic Chemistry
Quinazolinone synthesis and applications
article

A Solvent‐Free One‐Pot Synthesis of Ethyl 4‐Oxo‐3,4‐Dihydro Quinazoline‐2‐Carboxylates Utilizing N ‐(2‐Aminobenzoyl) Benzotriazoles

İlhami Çelik, Sultan Funda Ekti, Nasir Ahmad Heravi
article en

Abstract

ABSTRACT A new solvent‐free one‐pot method for the synthesis of ethyl 4‐oxo‐3,4‐dihydroquinazoline‐2‐carboxylates using N ‐(2‐aminobenzoyl) benzotriazoles was developed. In this method, ethyl 4‐oxo‐3,4‐dihydroquinazoline‐2‐carboxylates were obtained in good yields (20%–85%) by the reaction of N ‐(2‐amino benzoyl) benzotriazoles with diethyl oxalate and ammonium acetate in the absence of solvent.

Journal of Heterocyclic ChemistryVol. 62(12)
Eskisehir Technical University (TR)
Openalex Percentile: Top 81%
Quinazolinone synthesis and applications
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