Intergenerational metabolic toxicity of perfluorooctanesulfonic acid exposure in adult offspring rats: a multi-omics approach
Early-life exposure to PFOS might lead to metabolic perturbations in adult offspring, which might be triggered by changes in pathways, i.g. glycerophospholipid metabolism, retinol metabolism, linoleic acid metabolism, and fatty acid elongation. Further validation of these pathways is required.
Authors
- Yan Sun (ORCID: https://orcid.org/0000-0001-7911-0963)
- Meng Xi (ORCID: https://orcid.org/0000-0001-8207-3921)
- Tingyu Luo (ORCID: https://orcid.org/0000-0001-5839-213X)
- Liping Feng (ORCID: https://orcid.org/0000-0002-2936-7397)
- Xiaona Huo (ORCID: https://orcid.org/0000-0003-3128-8089)
- Jun Zhang (ORCID: https://orcid.org/0000-0003-1706-1611)
- Yongjie Liu (ORCID: https://orcid.org/0000-0001-7301-9501)
- Guoqi Yu
Institutions
- National University of Singapore (SG)
- Guilin Medical University (CN)
- XinHua Hospital (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Duke Medical Center (US)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3389/fendo.2025.1589826
- Citations
- 1
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.86