Interpretable prediction of coronary heart disease risk in adults over 50 with accelerated aging using 45 dietary nutrients

Among adults aged 50 and older with accelerated aging, higher intake of specific dietary nutrients was associated with reduced CHD risk. Of the machine learning models tested, the random forest algorithm demonstrated the strongest predictive performance. SHAP and LIME analyses jointly highlighted vitamin B12 and lutein + zeaxanthin as key contributors to the reduced CHD risk in this high-risk population.