Follicular fluid-derived small extracellular vesicles during individual in vitro maturation improve blastocyst development
We propose that intercellular communication in group cultures, potentially mediated by endogenous embryotropins (including sEVs), may mask FF-sEVs benefits. In individual systems, where such interactions are absent (or minimal), FF-sEVs significantly improved embryo competence. These findings underscore FF-sEVs as a promising tool to refine assisted reproductive technologies, contingent on culture conditions.
Authors
- Krishna Chaitanya Pavani (ORCID: https://orcid.org/0000-0001-7043-1007)
- Camilla Benedetti (ORCID: https://orcid.org/0000-0001-7904-7175)
- Nima Azari‐Dolatabad (ORCID: https://orcid.org/0000-0002-9242-6994)
- Jo Leroy (ORCID: https://orcid.org/0000-0002-2262-9403)
- Osvaldo Bogado Pascottini (ORCID: https://orcid.org/0000-0002-5305-2133)
- Ann Van Soom (ORCID: https://orcid.org/0000-0001-5010-6311)
- Davoud Eshghi
- GEERT OPSOMER (ORCID: https://orcid.org/0000-0002-6131-1000)
- An Hendrix (ORCID: https://orcid.org/0000-0002-1883-8309)
- Lei Xie (ORCID: https://orcid.org/0000-0001-6537-7632)
- Sarah E. Moorey (ORCID: https://orcid.org/0000-0001-9243-3863)
- Andrea Fernández Montoro
- Fabiola Le Graffric Molto
Institutions
- University College Dublin (IE)
- University of Antwerp (BE)
- Ghent University Hospital (BE)
- Ghent University (BE)
- University of Göttingen (DE)
- University of Tennessee at Knoxville (US)
- Ferdowsi University of Mashhad (IR)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3389/fvets.2025.1644542
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering