Identification of prognostic and cellular senescence gene E2F1 of papillary thyroid carcinoma through bioinformatics analyses and experimental verification
E2F1 was found to be upregulated in PTC, with its high expression significantly correlated to a favorable patient prognosis. E2F1 suppresses malignant tumor phenotypes by modulating cellular senescence. A predictive model integrating E2F1 and clinical features accurately forecasts poor prognosis, indicating E2F1's potential as a therapeutic target for PTC.
Authors
- Yi‐Lin Shen
- Shuyan Zhao (ORCID: https://orcid.org/0000-0001-5316-0858)
- Ke Zheng (ORCID: https://orcid.org/0000-0001-5294-8918)
- Bairong Shen (ORCID: https://orcid.org/0000-0003-2899-1531)
- Junjie Luo (ORCID: https://orcid.org/0000-0002-8987-0533)
- Bin Yu (ORCID: https://orcid.org/0000-0003-1567-8415)
- Haitian Zhong (ORCID: https://orcid.org/0009-0002-4741-3411)
- Yunhua Zhu
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3389/fgene.2025.1605385
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00