Neurological and neuropsychological correlates of Klippel-Feil syndrome
GDF6, a gene associated with KFS, plays a role in retinotectal mapping, which organizes visual stimuli in the brain. Early neurodevelopment abnormalities, such as atlanto-occipital anomalies in KFS, might affect related brain structures, which could explain the patient's impaired visuospatial function. In addition, compensatory neuroplasticity underscores how the brain may adapt to congenital defects, even severe ones.
Authors
- Loris Di Clemente
- Stefano Luca Sensi (ORCID: https://orcid.org/0000-0002-0710-2574)
- Astrid Thomas (ORCID: https://orcid.org/0000-0003-3853-2996)
- Mirella Russo (ORCID: https://orcid.org/0000-0002-9937-5923)
- Dario Calisi (ORCID: https://orcid.org/0000-0002-0584-7812)
- Valentina Panara (ORCID: https://orcid.org/0000-0001-9655-3926)
- Sara Melchiorre
- Matteo Santilli
- Gaetano Polito
- Consuelo Ciprietti
Institutions
- University of Chieti-Pescara (IT)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1007/s10072-025-08454-7
- Primary Topic
- Spinal Fractures and Fixation Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00