Relationship between lung function impairment, clinical characteristics and systemic inflammation based on a large-scale population screening
In a large-scale screening, individuals with airflow obstruction and PRISm present with distinct clinical phenotypes. A predictive model using simple clinical variables can help identify individuals at higher risk for lung function impairment, despite modest performance. Serum IL-2, IL-5, and IL-17A are potential biomarkers for the early recognition and understanding of airflow limitation.
Authors
- Qi Wu (ORCID: https://orcid.org/0000-0001-9879-5056)
- Chunting Chen
- Zhancheng Gao (ORCID: https://orcid.org/0000-0001-7415-1416)
- Long Cheng (ORCID: https://orcid.org/0000-0003-4347-7469)
- Kaiyu Ma
- Shuming Guo
- Wenxia Guan
- Mengtong Jin
- Xiaojun Ma
- Peng Liu (ORCID: https://orcid.org/0000-0002-9639-6606)
- Ran Li (ORCID: https://orcid.org/0000-0002-9820-0961)
- Yan Yu (ORCID: https://orcid.org/0009-0003-0391-8474)
- Yujie Zhou (ORCID: https://orcid.org/0000-0002-4528-6087)
Institutions
- Shanxi Medical University (CN)
- Peking University (CN)
- Tianjin Medical University General Hospital (CN)
- Xian Central Hospital (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3389/fmed.2025.1657151
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52