Human pluripotent stem cell–derived neuronal progenitor cells promote neurogenesis and functional recovery by attenuating neuroinflammation and via extracellular vesicles in a subacute stroke model
NPC administration during the subacute phase of stroke promoted functional recovery by promoting neurogenesis and modulating key survival pathways. These results highlight the therapeutic potential of NPCs as cell-based interventions for delayed stroke treatment and provide mechanistic insights into their reparative effects.
Authors
- Jee In Choi
- Sangyong Jung (ORCID: https://orcid.org/0000-0003-3017-1145)
- MinYoung Kim (ORCID: https://orcid.org/0000-0001-5481-2985)
- Hyun Jin Kim (ORCID: https://orcid.org/0000-0002-6760-4963)
- Dong Hee Kim (ORCID: https://orcid.org/0000-0003-3940-5315)
- Dong‐Youn Hwang (ORCID: https://orcid.org/0000-0002-2332-9461)
- Hyeonsub Sim
Institutions
- CHA University Bundang Medical Center (KR)
- CHA University (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1650092
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00