Mechanistic models position ceritinib as a nuclear integrity disrupting therapy in pediatric liver tumors
This study demonstrates the successful application of mechanistic models on virtual patients to position ceritinib as a promising therapeutic agent for high-risk pediatric liver tumors, highlighting its impact on key kinases implicated in tumor aggressiveness and its ability to compromise nuclear integrity.
Authors
- Émilie Indersie (ORCID: https://orcid.org/0000-0001-8974-6551)
- Tomoro Hishiki (ORCID: https://orcid.org/0000-0002-2515-1054)
- Eiso Hiyama (ORCID: https://orcid.org/0000-0001-9179-5037)
- Stefano Cairo (ORCID: https://orcid.org/0000-0002-4725-5970)
- Bodo Lange
- Mathurin Dorel (ORCID: https://orcid.org/0000-0002-1663-2075)
- Roland Kappler (ORCID: https://orcid.org/0000-0002-8581-2803)
- T. Keßler (ORCID: https://orcid.org/0000-0002-1693-4444)
- Christian Vokuhl (ORCID: https://orcid.org/0000-0002-4138-4536)
- Alina Hotes
- Salih Demir (ORCID: https://orcid.org/0009-0009-3478-1136)
- Hans Lehrach (ORCID: https://orcid.org/0000-0003-4050-0176)
- Beate Häberle
- Sophie Branchereau
Institutions
- Hiroshima University (JP)
- Chiba University (JP)
- Université Paris-Saclay (FR)
- University Hospital Bonn (DE)
- LMU Klinikum (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Champions Oncology (United States) (US)
- Max Planck Institute for Molecular Genetics (DE)
- Alacris (Germany) (DE)
- Bicêtre Hospital (FR)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1186/s13046-025-03535-z
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00