Preliminary exploration of the ability of HUC-MSCs to restore the lung microbiota and related metabolite disorders in IPF treatment: combining 16S sequencing and metabolite analysis
Overall, our study preliminarily confirmed that IPF in mice was closely related to microbial and metabolic dysbiosis. In mice with IPF, treatment with HUC-MSCs modulated dysregulated metabolic pathways and improved microbiota function to a state more comparable to that of the Control group. This study provides new insights into the potential mechanisms and treatments of IPF.
Authors
- Yizhou Lin (ORCID: https://orcid.org/0009-0007-9249-8107)
- Qing-chun Jia (ORCID: https://orcid.org/0000-0002-8225-8288)
- Jin Huang (ORCID: https://orcid.org/0009-0002-0787-3915)
- Yukai Luo
- Wenzhao Cheng (ORCID: https://orcid.org/0000-0002-0394-2082)
- Xiaojing Zhang (ORCID: https://orcid.org/0000-0003-1795-4399)
- Jun Liu (ORCID: https://orcid.org/0000-0003-0097-078X)
- Zheng Huang (ORCID: https://orcid.org/0000-0002-7245-0620)
- Shuang Zhou (ORCID: https://orcid.org/0000-0002-4188-5496)
- Yiming Zeng (ORCID: https://orcid.org/0000-0001-5635-3006)
Institutions
- Fujian Medical University (CN)
- Longyan University (CN)
- The 180th Hospital of PLA (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.3389/fmicb.2025.1645577
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China