Genetiske diagnoser som medfører utviklingsforstyrrelser i emalje og dentin

Genetic diagnoses leading to developmental disturbances in enamel and dentine –the important role of dental health professionals Teeth have been described as the body's flight recorder because they can reflect a range of genetic changes, autoimmune conditions, dental trauma, systemic disorders, and environmental influences. These factors can impact amelogenesis and dentinogenesis, leading to dental developmental disorders in the hard tissue of teeth. Thorough investigation of these disorders is essential, as they may be linked to broader diseases and syndromes. Disorders that affect dental tissue, such as enamel and dentin, can have either genetic or non-genetic causes. Identifying potential connections between dental developmental disorders and extra-oral symptoms is crucial for dental health professionals, as it may aid in the diagnosis of underlying syndromes. A holistic approach that considers the “whole individual” is key to recognizing these associations. Highlighted examples include autoimmune polyendocrine syndrome type 1 and coeliac disease (APS1), tricho-dento-osseous syndrome, and hypophosphatasia. The importance of systematic diagnosis, interdisciplinary collaboration, and the potential role of genetic testing are emphasized. Many patients will require personalized follow-up and treatment throughout their lives, making early diagnosis essential to ensuring the best possible care both in the short and long term.