Six‐pattern p53 interpretation in 1293 vulvar squamous cell carcinomas: inter‐pathologist variation and pattern distribution according to p16 status
Findings support the clinical robustness of the six-pattern p53 framework, as interobserver agreement was high and most discrepancies were unlikely to impact tumour classification. While p16 proved helpful in p53 interpretation, certain cases remained challenging due to p53 heterogeneity or ambiguous p16/p53 combinations indicating a need for additional molecular testing in such instances.
Authors
- Else Mejlgaard (ORCID: https://orcid.org/0000-0003-2714-2394)
- Doris Schledermann (ORCID: https://orcid.org/0000-0003-4272-718X)
- Marianne Waldstrøm
- Emma L. Kaderly Rasmussen (ORCID: https://orcid.org/0009-0005-7466-631X)
- Kirsten Frederiksen (ORCID: https://orcid.org/0000-0001-7919-6613)
- Susanne K. Kjær (ORCID: https://orcid.org/0000-0002-8347-1398)
- Birgitte Hjelm Winberg
- Tatiana Hansen
- Lise Grupe Larsen
- Louise Baandrup (ORCID: https://orcid.org/0000-0002-5773-5169)
- N. Salinas
- Alexander K. Kjær (ORCID: https://orcid.org/0000-0002-4614-8743)
- M B Franzmann
Institutions
- University of Copenhagen (DK)
- Aarhus University (DK)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Herlev Hospital (DK)
- Hvidovre Hospital (DK)
- Aarhus University Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
- Lillebaelt Hospital (DK)
- Danish Cancer Society (DK)
Publication Details
- Journal
- Histopathology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1111/his.15561
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Region Sjælland