Nrf2 Deficiency in Müller Cells Exacerbates Pathological Neovascularization in Ischemic Retinopathy
Nrf2 in Müller cells plays an integral protective role in modulating retinal angiogenesis and inflammatory responses in ischemic retinopathy. Nrf2 is an important regulator of Müller cell state in retinal ischemia and governs the Müller cell transcriptional program, including LCN2, a novel regulator of angiogenesis. This highlights pharmacological activation of Nrf2 as a therapeutic strategy for pathological neovascularization in ischemic retinopathy.
Authors
- Lingli Zhou (ORCID: https://orcid.org/0000-0002-9321-9348)
- Yangyiran Xie (ORCID: https://orcid.org/0000-0001-9194-2439)
- Elia J. Duh (ORCID: https://orcid.org/0000-0003-1917-373X)
- S.X. Wu
- Hongkwan Cho (ORCID: https://orcid.org/0000-0002-1409-5886)
- Zhenhua Xu
- L. P. Shi (ORCID: https://orcid.org/0009-0004-2751-1174)
- Yingxue Cao
- Jie Wang (ORCID: https://orcid.org/0000-0002-7491-7001)
- Jiang Qian (ORCID: https://orcid.org/0000-0002-0476-3596)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1161/atvbaha.125.323301
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41